Learn how PrEP (pre‑exposure prophylaxis) with generic Truvada (TDF/FTC) and generic Descovy (TAF/FTC) helps prevent HIV. This expert‑reviewed guide covers how PrEP pills work, 2‑1‑1 PrEP dosing, PrEP effectiveness (99%), side effects, PrEP for women (pregnancy & breastfeeding), and time to protection—plus TDF vs TAF differences.
PrEP Basics & Effectiveness
What is PrEP and how effective is it?
PrEP (Pre-Exposure Prophylaxis) is a daily oral medication for HIV-negative people. It works by blocking the HIV virus from replicating in the body. According to global health authorities, PrEP reduces the risk of getting HIV from sex by about 99% when taken consistently. It is one of the most powerful tools for HIV prevention available today.
Are generic medications like Ricovir-EM or Tenvir-EM as effective as Truvada?
Yes. The generic options we offer—Ricovir-EM, Tenvir-EM, and Tenof-EM—are bioequivalent to the brand-name Truvada. They contain the exact same active ingredients (Tenofovir Disoproxil and Emtricitabine) in the same 300mg/200mg dosage. They offer identical protection against HIV but are significantly more affordable.
What is the difference between TDF (Ricovir/Tenvir) and TAF (Tafero/Taficita)?
We offer two formulas. TDF (found in Ricovir-EM, Tenvir-EM, and Tenof-EM), is the original formula equivalent to Truvada. TAF (found in Tafero-EM and Taficita-EM), is a newer formula equivalent to Descovy that achieves effective drug levels with a smaller dose. TAF is often preferred for users over 50 or those concerned about long-term kidney or bone health.
Can I use PrEP as a substitute for condoms?
PrEP protects against HIV but does not protect against other Sexually Transmitted Infections (STIs) like syphilis, gonorrhea, or chlamydia. Condoms provide dual protection against STIs and unintended pregnancy. Many users choose to use both strategies for complete sexual health coverage.
How long does it take for PrEP to become effective?
Maximum protection is reached after 5 days of daily use. It is critical to use additional protection (condoms) during this initial period.
Usage, Dosing & Daily Routine
How do I take PrEP correctly? (Daily vs. On-Demand)
There are two ways to take PrEP: 1) Daily PrEP: One pill every 24 hours. This is the recommended method for consistent protection for all genders. 2) On-Demand (2-1-1): Taking 2 pills 2-24 hours before sex, 1 pill 24 hours after the first dose, and 1 pill 24 hours after that.
Can I take PrEP with food or alcohol?
Yes. PrEP can be taken with or without food. Alcohol does not reduce the effectiveness of PrEP. However, heavy alcohol use might make you forget to take your pill, so setting a daily alarm is recommended to maintain adherence.
What is the best time of day to take PrEP?
You can take PrEP at any time of day that fits your schedule, as long as you take it at roughly the same time every 24 hours. Some users prefer taking it with breakfast to build a routine, while others take it before bed if it causes mild nausea.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your regular schedule. Do not take two pills at once. Consistent adherence is key to maintaining the 99% effectiveness rate.
Can I crush the pill if I have trouble swallowing?
Yes. If you have difficulty swallowing pills, you can crush the generic Truvada or Descovy tablet and mix it with a small amount of water, juice, or soft food (like yogurt). Consume the mixture immediately to ensure you get the full dose.
Switching & Stopping PrEP
Can I switch from TDF (Ricovir) to TAF (Tafero)?
Yes, switching is generally safe. If you want to switch to a TAF-based formula like Tafero-EM to reduce kidney impact, simply take your first dose of the new medication 24 hours after your last dose of the old one. There is no gap in coverage.
How do I safely stop taking PrEP?
If you wish to stop, you should generally continue taking PrEP for 2 days (for anal sex risk) after your last potential exposure to HIV. Consult a healthcare provider before stopping to ensure you are fully protected during the washout period.
Can I restart PrEP after stopping?
Yes. If you have stopped PrEP and want to restart, you must get a new HIV test to confirm you are still HIV-negative. Starting PrEP while HIV-positive can lead to drug resistance. Once confirmed negative, you can restart the daily regimen.
Safety, Health & Travel
What are the common side effects?
Oral PrEP is well-tolerated. Some users experience mild "start-up" side effects like nausea, headache, or stomach upset during the first few weeks, which typically resolve on their own. Serious long-term side effects are rare.
Does PrEP affect bone density or kidneys?
In rare cases, TDF-based PrEP can cause a slight, often reversible decrease in kidney function or bone density. For users with existing risk factors, the TAF formula (Tafero-EM) is often recommended as it has a more neutral safety profile regarding bones and kidneys.
Does PrEP interact with gender-affirming hormones?
No. PrEP is safe for transgender people. Research shows that PrEP does not lower hormone levels, and hormones do not lower PrEP effectiveness. You can safely take PrEP alongside Estrogen or Testosterone therapies.
Does PrEP interact with recreational drugs?
PrEP has no known significant interactions with common recreational drugs (such as alcohol, poppers, ecstasy, or cocaine). However, using clean needles is essential if injecting drugs, as PrEP protects against sexual transmission but harm reduction is still key.
Can I travel with my PrEP medication?
Yes. You can travel with PrEP. We recommend keeping the medication in its original bottle with the label intact. If traveling internationally, check the local laws regarding medication importation of the destination country, although personal supplies are generally permitted.
Can I take PrEP if I am pregnant or breastfeeding?
Current guidelines suggest that PrEP can be used during pregnancy and breastfeeding if the risk of HIV acquisition is high. Preventing HIV in the parent is the best way to prevent HIV in the baby. Always consult your doctor for a personalized risk/benefit assessment.
What medical tests are required while on PrEP?
While on PrEP, it is standard practice to test for HIV every 3 months to ensure you remain negative. Kidney function (creatinine) should typically be checked every 6 to 12 months, along with regular screening for other STIs.
Medical Disclaimer: This FAQ is for informational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing PrEP.
Medical References
- CDC: PrEP Effectiveness & Guidelines
- EACS: Guidelines on PrEP Dosing
- NAM aidsmap: Generic PrEP Facts & Safety
- UCSF Transgender Care: PrEP & Hormone Interactions
Last Medically Reviewed: November 28, 2025
Reviewed by: Dr. James Mitchell, Consultant in Sexual Health & HIV Medicine (GMC Registered).